of clinical expertise/research interests:
The laboratory of Dr. Peter S. McPherson, James McGill Professor uses biochemical, molecular, structural and cellular approaches to identify and functionally characterize proteins that function in membrane trafficking in neurons. A number of the proteins identified in the McPherson laboratory have been linked to neurological diseases including schizophrenia, Huntington's disease, hereditary spastic paraplegias (ALS-like), and autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Indeed, dysregulation of membrane trafficking is emerging as a central theme in neurodegenerative diseases. Understanding the cell biological basis of neurological disease is a focus of the laboratory.